Radiosensitizing effect of plumbagin on mouse melanoma cells grown in vitro.

  title={Radiosensitizing effect of plumbagin on mouse melanoma cells grown in vitro.},
  author={Velisetty S. Prasad and Pathirissery Uma Devi and Bola Sadashiva Satish Rao and Ravindra Kamath},
  journal={Indian journal of experimental biology},
  volume={34 9},
Mouse melanoma cells were treated with plumbagin, a naphthoquinone, from the plant Plumbago rosea at 0.5 microgram/ml (PI) for 60 min either alone or followed by 2 Gy gamma radiation (RT). Response to the different treatments was assessed by following the cell growth up to 5 days post treatment. PI alone produced a significant decrease in the cell count on days 3 and 4, whereas RT treatment significantly enhanced the growth inhibitory effect when compared to RT or PI alone. These findings… CONTINUE READING

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