Radiosensitization of mouse sarcoma cells by fludarabine (F-ara-A) or gemcitabine (dFdC), two nucleoside analogues, is not mediated by an increased induction or a repair inhibition of DNA double-strand breaks as measured by pulsed-field gel electrophoresis.

@article{Grgoire1998RadiosensitizationOM,
  title={Radiosensitization of mouse sarcoma cells by fludarabine (F-ara-A) or gemcitabine (dFdC), two nucleoside analogues, is not mediated by an increased induction or a repair inhibition of DNA double-strand breaks as measured by pulsed-field gel electrophoresis.},
  author={Vincent Gr{\'e}goire and Marc Beauduin and Monique Bruniaux and Blanche M De Coster and M Octave Prignot and Pierre Scalliet},
  journal={International journal of radiation biology},
  year={1998},
  volume={73 5},
  pages={511-20}
}
PURPOSE To investigate the effect of fludarabine (F-ara-A) and gemcitabine (dFdC), two radiosensitizing nucleoside analogues, on the induction and repair of DNA dsb after ionizing radiation. MATERIALS AND METHODS Radiosensitization of mouse sarcoma SA-NH and FSA cells was studied using a clonogenic assay. Cell survival curves were fitted with the linear-quadratic model. DNA dsbs were detected by pulsed-field gel electrophoresis under neutral conditions. RESULTS F-ara-A (100 micromol dm(-3… CONTINUE READING

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