Radiosensitization of Primary Human Glioblastoma Stem-like Cells with Low-Dose AKT Inhibition.

@article{Mehta2015RadiosensitizationOP,
  title={Radiosensitization of Primary Human Glioblastoma Stem-like Cells with Low-Dose AKT Inhibition.},
  author={Monal Mehta and Atif J. Khan and Shabbar F. Danish and Bruce G. Haffty and Hatem E Sabaawy},
  journal={Molecular cancer therapeutics},
  year={2015},
  volume={14 5},
  pages={1171-80}
}
Glioblastoma (GBM) is the most frequent and lethal brain cancer. The lack of early detection methods, the presence of rapidly growing tumor cells, and the high levels of recurrence due to chemo- and radioresistance make this cancer an extremely difficult disease to treat. Emerging studies have focused on inhibiting AKT activation; here, we demonstrate that in primary GBM tumor samples, full-dose inhibition of AKT activity leads to differential responses among samples in the context of cell… CONTINUE READING