Radiosensitization of Human Leukemic HL-60 Cells by ATR Kinase Inhibitor (VE-821): Phosphoproteomic Analysis

@inproceedings{alovsk2014RadiosensitizationOH,
  title={Radiosensitization of Human Leukemic HL-60 Cells by ATR Kinase Inhibitor (VE-821): Phosphoproteomic Analysis},
  author={Barbora {\vS}alovsk{\'a} and Ivo Fabrik and Kamila Ďuri{\vs}ov{\'a} and Marek Link and Jiřina V{\'a}vrov{\'a} and Martina Řez{\'a}{\vc}ov{\'a} and Ale{\vs} Tich{\'y}},
  booktitle={International journal of molecular sciences},
  year={2014}
}
DNA damaging agents such as ionizing radiation or chemotherapy are frequently used in oncology. DNA damage response (DDR)-triggered by radiation-induced double strand breaks-is orchestrated mainly by three Phosphatidylinositol 3-kinase-related kinases (PIKKs): Ataxia teleangiectasia mutated (ATM), DNA-dependent protein kinase (DNA-PK) and ATM and Rad3-related kinase (ATR). Their activation promotes cell-cycle arrest and facilitates DNA damage repair, resulting in radioresistance. Recently… CONTINUE READING
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