Radiosensitization effects of berberine on human breast cancer cells.

@article{Wang2012RadiosensitizationEO,
  title={Radiosensitization effects of berberine on human breast cancer cells.},
  author={Jing Wang and Qiao Liu and Qifeng Yang},
  journal={International journal of molecular medicine},
  year={2012},
  volume={30 5},
  pages={
          1166-72
        }
}
Berberine, an isoquinoline derivative alkaloid, has recently been shown to have antitumor activity. The present study aimed to investigate the effects of the concomitant administration of berberine and radiation on breast cancer. The effects of berberine on the radiosensitivity of MCF-7 and MDA-MB-468 cells were evaluated by using cell clonogenic assays. Cells pre-treated with berberine or dimethyl sulfoxide (DMSO) for 24 h were irradiated using a Faxitron Cabinet X-ray System to deliver the… 
View on PubMed
spandidos-publications.com
41 Citations
Highly Influential Citations
2
Background Citations
19
Methods Citations
2
Results Citations
3

41 Citations

Citation Type

Citation Type

Berberine and chemotherapeutic drugs synergistically inhibits cell proliferation and migration of breast cancer cells
TLDR
Berberine showed synergistic effects in combination with chemotherapeutic drugs to remarkably inhibit cell proliferation and suppress cell migration of breast cancer cells.
Radiosensitization effect of Huaier on breast cancer cells.
TLDR
Huaier has the ability to sensitize breast cancer cells to radiotherapy through regulation of the cell cycle and DNA repair pathway, and may be a promising radiosensitizer for the treatment of breast cancer.
Berberine sensitizes nasopharyngeal carcinoma cells to radiation through inhibition of Sp1 and EMT.
Nasopharyngeal carcinoma (NPC) is a tumor of epithelial origin with radiotherapy as its standard treatment. However, radioresistance remains a critical issue in the treatment of NPC. This study aimed…
Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression
TLDR
Berberine efficiently radiosensitized NPC cells and xenografts in mice, and inhibited hypoxia/radiation-induced up-regulation of HIF-1α and VEGF expression.
Berberine can amplify cytotoxic effect of radiotherapy by targeting cancer stem cells
TLDR
IR and berberine treatment decreased the viability of MCF-7 spheroids and reduced OCT4 and SOX2 genes expression and showed to be a good candidate for further studies as a new anticancer drug in the treatment of breast cancer.
Berberine Reverses the Chemoresistance of Breast Cancer to 5- Fluorouracil by Downregulating Metadherin
TLDR
MTDH is a key oncogene, which plays an important role in chemoresistance to 5-Fu in breast cancer and berberine may reverse this resistance and improve the efficacy of 5- Fu to breast cancer.
A preliminary study on the synthetic lethal effect of berberine and olaparib on pancreatic cancer cells and its mechanism
TLDR
Berberine combined with olaparib have a synthetic lethal effect on pancreatic cancer cells and this effect can be reversed by apoptosis inhibitor and necrosis inhibitor.
The Natural Compound Gambogic Acid Radiosensitizes Nasopharyngeal Carcinoma Cells under Hypoxic Conditions
TLDR
The results of this study suggest that GA efficiently radiosensitizes NPC cells and the effect may be significant in hypoxic conditions.
Coralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle
TLDR
Results indicate that coralyne is a potent radiosensitizing agent that may find an application in medicine.
Berberine induces double-strand DNA breaks in Rev3 deficient cells.
TLDR
The results suggest that berberine is able to induce DNA damage, and that the Rev3 associated DNA repair pathway participates in the processes that aid its repair.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 38 REFERENCES
Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death.
Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage.
Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line.
TLDR
Berberine induces p53 expression and leads to the decrease of the mitochondrial membrane potential, Cytochrome C release and activation of caspase-3 for the induction of apoptosis.
Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51
TLDR
Berberine can effectively downregulate RAD51 in conferring radiosensitivity on esophageal cancer cells, and its clinical application as an adjuvant in chemotherapy and radiotherapy of esphageal cancers should be explored.
Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway.
TLDR
The data support that berberine initially induces an endoplasmic reticulum stress response based on ROS and Ca2+ production which is followed by dysfunctions of the mitochondria, resulting in apoptosis of these oral cancer HSC-3 cells.
Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells
TLDR
The effectiveness of berberine in checking the growth of androgens-insensitive, as well as androgen-sensitive, prostate cancer cells without affecting thegrowth of normal prostate epithelial cells indicates that it may be a promising candidate for prostate cancer therapy.
Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells
TLDR
It is demonstrated that berberine exhibited significant cytotoxicity in hepatoma HepG2 cells but is ineffective in Chang liver cells, and the potential of anti-hepatoma activity of berberines may be mediated through a caspases-mitochondria-dependent pathway.
Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells.
Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity.
TLDR
Data indicate that Gleevec enhances radiation-induced tumor cell killing and suggest that the mechanism involves the reduction in Rad51 levels, and suggests that Rad51 may be an appropriate target for selectively enhancing the radiosensitivity of brain tumor cells.
Down-Regulation of Rad51 Expression Overcomes Drug Resistance to Gemcitabine in Human Non–Small-Cell Lung Cancer Cells
TLDR
Constructs containing human Rad51 cDNA or specific Rad51 small interfering RNA (siRNA) were used to examine the role of Rad51 in chemoresistance of gemcitabine in three different human NSCLC cell lines and gem citabine-induced cytotoxicity was significantly increased.
...
1
2
3
4
...