Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis.

@article{Nol2006RadiosensitizationBT,
  title={Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis.},
  author={Georges No{\"e}l and Camille Godon and Marie Fernet and Nicole Giocanti and Fr{\'e}d{\'e}rique M{\'e}gnin-Chanet and Vincent Favaudon},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 3},
  pages={564-74}
}
Radiosensitization caused by the poly(ADP-ribose) polymerase (PARP) inhibitor 4-amino-1,8-naphthalimide (ANI) was investigated in 10 asynchronously growing rodent (V79, CHO-Xrs6, CHO-K1, PARP-1+/+ 3T3, and PARP-1-/- 3T3) or human (HeLa, MRC5VI, IMR90, M059J, and M059K) cell lines, either repair proficient or defective in DNA-PK (CHO-Xrs6 and M059J) or PARP-1 (PARP-1-/- 3T3). Pulse exposure to ANI (1-hour contact) potentiated radiation response in rodent cells except in PARP-1(-/-) 3T3… CONTINUE READING

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Cell type dependent

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1 Excerpt

Molecular Cancer Therapeutics 573 Mol Cancer Ther 2006;5(3)

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