Radiosensitization by inhibiting STAT1 in renal cell carcinoma.

  title={Radiosensitization by inhibiting STAT1 in renal cell carcinoma.},
  author={Zhouguang Hui and Maria M Tretiakova and Zhongfa Zhang and Yan Li and Xiaozhen Wang and Julie Xiaohong Zhu and Yuan-hong Gao and Weiyuan Mai and Kyle A. Furge and Chao-nan Qian and Robert J. Amato and Edward Brian Butler and Bin Tean Teh and Bin S. Teh},
  journal={International journal of radiation oncology, biology, physics},
  volume={73 1},
PURPOSE Renal cell carcinoma (RCC) has been historically regarded as a radioresistant malignancy, but the molecular mechanism underlying its radioresistance is not understood. This study investigated the role of signal transducer and activator of transcription 1 (STAT1), a transcription factor downstream of the interferon-signaling pathway, in radioresistant RCC. METHODS AND MATERIALS The expressions of STAT1 and STAT3 in 164 human clear cell RCC samples, 47 papillary RCC samples, and 15… CONTINUE READING