Radiosensitization by fluorodeoxyuridine: effects of thymidylate synthase inhibition and cell synchronization.

Abstract

The combination of fluoropyrimidines and radiation has resulted in increased control of colorectal cancer in the clinic, but the basic mechanism of the interaction is not understood clearly. Preliminary work in our laboratory showed that 2-h exposures of HT 29 human colon carcinoma cells to relatively low levels of 5-fluorodeoxyuridine resulted in extended… (More)

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