Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer.

@article{Schwartz2010RadiosensitizationAS,
  title={Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer.},
  author={David Schwartz and James A Bankson and Robert Lemos and Stephen Y Lai and Arun Kumar Thittai and Yi He and Galen H. Hostetter and Michael J. Demeure and Daniel D. Von Hoff and Garth Powis},
  journal={Molecular cancer therapeutics},
  year={2010},
  volume={9 7},
  pages={2057-67}
}
Growing tumors are hypoxic and respond to microenvironmental stress through increased expression of the hypoxia inducible factor-1alpha (HIF-1alpha) transcription factor, resulting in an adaptive switch to glycolytic metabolism, angiogenic signaling, survival, and metastasis. HIF-1alpha expression is associated with tumor resistance to cytotoxic therapy and inferior patient outcomes. Pancreatic cancer is the most hypoxic of all solid tumors and remains refractory to current chemoradiotherapy… CONTINUE READING