Radiosensitivity in ataxia-telangiectasia: a new explanation.

@article{Painter1980RadiosensitivityIA,
  title={Radiosensitivity in ataxia-telangiectasia: a new explanation.},
  author={Robert B. Painter and Barry R. De Young},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 12},
  pages={7315-7}
}
The cause of increased radiosensitivity in ataxia-telangiectasia (AT) cells may be a defect in their ability to respond to DNA damage rather than a defect in their ability to repair it. Doses of x-radiation that markedly inhibited the rate of DNA synthesis in normal human cells caused almost no inhibition in AT cells and thus less delay during which x-ray damage could be repaired. The radioresistance of DNA synthesis in AT cells was primarily due to a much smaller inhibition of replicon… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 197 extracted citations

List of Papers

I Simonsson, † Qvarnström
2010
View 13 Excerpts
Highly Influenced

A low-dose hypersensitive keratinocyte loss in response to fractionated radiotherapy is associated with growth arrest and apoptosis.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology • 2010
View 5 Excerpts
Highly Influenced

Radiation and the cell cycle, revisited

Cancer and Metastasis Reviews • 2004
View 5 Excerpts
Highly Influenced

An ATM-independent S-phase checkpoint response involves CHK1 pathway.

Cancer research • 2002
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…