Radiosensitivity in ataxia-telangiectasia: a new explanation.

  title={Radiosensitivity in ataxia-telangiectasia: a new explanation.},
  author={Robert B. Painter and Barry R. De Young},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={77 12},
The cause of increased radiosensitivity in ataxia-telangiectasia (AT) cells may be a defect in their ability to respond to DNA damage rather than a defect in their ability to repair it. Doses of x-radiation that markedly inhibited the rate of DNA synthesis in normal human cells caused almost no inhibition in AT cells and thus less delay during which x-ray damage could be repaired. The radioresistance of DNA synthesis in AT cells was primarily due to a much smaller inhibition of replicon… CONTINUE READING
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