Radioresistance induced by the high molecular forms of the basic fibroblast growth factor is associated with an increased G2 delay and a hyperphosphorylation of p34CDC2 in HeLa cells.

@article{CohenJonathan1997RadioresistanceIB,
  title={Radioresistance induced by the high molecular forms of the basic fibroblast growth factor is associated with an increased G2 delay and a hyperphosphorylation of p34CDC2 in HeLa cells.},
  author={Elizabeth Moyal Cohen-Jonathan and Christine Toulas and S. Monteil and Bettina Couderc and Ariette Maret and J. Bard and H. Prats and Nicolas Daly-Schveitzer and Gilles Favre},
  journal={Cancer research},
  year={1997},
  volume={57 7},
  pages={1364-70}
}
The basic fibroblast growth factor-(bFGF) mediated signal transduction pathway has been implicated in cellular resistance to ionizing radiation. bFGF is synthesized from the same mRNA in four isoforms resulting from alternative initiations of translation at three CUG start codons (24, 21.5, and 21 kDa) and one AUG start codon (18 kDa). We analyzed the implication of high- and low-molecular forms of bFGF in radioresistance acquisition. For this, we transfected HeLa cells with retroviral vector… CONTINUE READING