Radioreceptor assay for serum levels of cetamolol, a new beta-adrenoceptor antagonist.

@article{Stern1984RadioreceptorAF,
  title={Radioreceptor assay for serum levels of cetamolol, a new beta-adrenoceptor antagonist.},
  author={M. Stern},
  journal={Clinical biochemistry},
  year={1984},
  volume={17 3},
  pages={
          162-5
        }
}
  • M. Stern
  • Published 1984
  • Chemistry, Medicine
  • Clinical biochemistry
Cetamolol hydrochloride, viz 2-[2-[3-(1,1-dimethylethyl)amino-2-hydroxy-propoxy]phenoxy]-N- methylacetamide hydrochloride, is a potent beta-adrenoceptor antagonist with moderate cardioselectivity and intrinsic sympathomimetic activity. In support of ongoing clinical trials, a radioreceptor assay has been developed to measure serum drug levels. In this assay, serum extracts containing cetamolol compete with [3H]-dihydroalprenolol for rat lung binding sites. This method which is sensitive to 1 ng… Expand
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Dosing recommendations are suggested for patients who have compromised renal function because of the effects of renal function on the pharmacokinetic parameters of cetamolol, as the severity of renal impairment increased. Expand
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Atenolol and sotalol were assessed as dialyzable in patients with kidney impairment, and the workgroup suggests ECTR in patients severely poisoned with these drugs when aforementioned indications are present, whereas other BAAs were considered Dialyzable, clinical data were too limited to develop recommendations. Expand

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TLDR
The radioreceptor assay is simple to perform, sensitive, detecting low nanomolar concentrations of plasma propranolol, and it is specific, detecting all pharmacologically active metabolites of β-blocking drugs as well as the parent drug. Expand
Measurement of beta-adrenoceptor antagonists in biological fluids using a radioreceptor assay.
TLDR
A new assay for plasma levels of beta-adrenoceptor antagonists is described, which is simple to perform, very sensitive and does not require prior extraction of plasma. Expand