Radioreceptor assay for serum levels of cetamolol, a new beta-adrenoceptor antagonist.

  title={Radioreceptor assay for serum levels of cetamolol, a new beta-adrenoceptor antagonist.},
  author={M. Stern},
  journal={Clinical biochemistry},
  volume={17 3},
  • M. Stern
  • Published 1984
  • Chemistry, Medicine
  • Clinical biochemistry
Cetamolol hydrochloride, viz 2-[2-[3-(1,1-dimethylethyl)amino-2-hydroxy-propoxy]phenoxy]-N- methylacetamide hydrochloride, is a potent beta-adrenoceptor antagonist with moderate cardioselectivity and intrinsic sympathomimetic activity. In support of ongoing clinical trials, a radioreceptor assay has been developed to measure serum drug levels. In this assay, serum extracts containing cetamolol compete with [3H]-dihydroalprenolol for rat lung binding sites. This method which is sensitive to 1 ng… Expand
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