Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine

@article{Bymaster1996RadioreceptorBP,
  title={Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine},
  author={F. Bymaster and D. Calligaro and J. Falcone and Richard D Marsh and N. Moore and N. Tye and P. Seeman and D. Wong},
  journal={Neuropsychopharmacology},
  year={1996},
  volume={14},
  pages={87-96}
}
The affinities of olanzapine, clozapine, haloperidol, and four potential antipsychotics were compared on binding to the neuronal receptors of a number of neurotransmitters. In both rat tissues and cell lines transfected with human receptors olanzapine had high affinity for dopamine D1, D2, D4, serotonin (5HT)2A, 5HT2C, 5HT3, α1-adrenergic, histamine H1, and five muscarinic receptor subtypes. Olanzapine had lower affinity for α2-adrenergic receptors and relatively low affinity for 5HT1 subtypes… Expand
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