Radioprotective effects of valproic acid, a histone deacetylase inhibitor, in the rat brain.

@article{Zhou2015RadioprotectiveEO,
  title={Radioprotective effects of valproic acid, a histone deacetylase inhibitor, in the rat brain.},
  author={Yong Zhou and Junjie Niu and Shupeng Li and Huaying Hou and Ying Xu and Wei Zhang and Yuhua Jiang},
  journal={Biomedical reports},
  year={2015},
  volume={3 1},
  pages={63-69}
}
Radiotherapy is commonly used in the treatment of brain tumors but can cause significant damage to surrounding normal brain. The radioprotective effects of valproic acid (VPA) on normal tissue in the rat brain were evaluated following irradiation. Male Wistar rats were used in the present study and 48 rats were randomly divided into four groups consisting of 12 rats each. The whole-brain irradiation (WBI) was delivered by X-ray and the rats received the following treatment once a day for 5 days… CONTINUE READING