Radioprotective effects of melatonin on radiation-induced cataract.

  title={Radioprotective effects of melatonin on radiation-induced cataract.},
  author={Ihsan Karslioĝlu and Mustafa Vecdi Ertekin and Seyithan Taysi and Ibrahim Koçer and Orhan Sezen and Akçahan Gepdiremen and Mehmet Koç and Nuri Bakan},
  journal={Journal of radiation research},
  volume={46 2},
One of the mechanisms proposed to explain lens opacification is the oxidation of crystallins, either by radiation or reactive oxygen species (ROS). It has been shown that melatonin has both an anti-peroxidative effect on several tissues and a scavenger effect on ROS. The purpose of this study was to determine the antioxidant role of melatonin (5 mg/kg/day) against radiation-induced cataract in the lens after total-cranium irradiation of rats with a single dose of 5 Gy. Sprague-Dawley rats were… CONTINUE READING


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