Radioprotection of plasmid and cellular DNA and Swiss mice by silibinin.

Abstract

The radioprotective effect of a non-toxic bioactive component in plant milk thistle, silibinin against genotoxicity induced by gamma-irradiation was investigated in vivo/in vitro. Under in vitro conditions of irradiation, silibinin protected plasmid pBR322 DNA against gamma-radiation-induced strand breaks in a concentration dependent manner (0-200microM… (More)
DOI: 10.1016/j.mrgentox.2009.11.007

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