Radioprotection of cultured Chinese hamster ovary cells by WR-255591.

@article{Murray1988RadioprotectionOC,
  title={Radioprotection of cultured Chinese hamster ovary cells by WR-255591.},
  author={D. Murray and E. Altschuler and M. S. Kerr and S. C. Vanankeren and R. Meyn and L. Milas},
  journal={International journal of radiation biology},
  year={1988},
  volume={54 2},
  pages={
          269-83
        }
}
We examined the radioprotective effect of the aminothiol WR-255591 and its phosphorothioate derivative WR-3689 on aerated cultured Chinese hamster ovary cells. At concentrations up to 10 mmol dm-3, WR-3689 afforded little protection from the lethal effects of gamma-radiation. The free thiol WR-255591, on the other hand, efficiently protected these cells, giving a protection factor (PF) for cell survival of 2.3 at a concentration of 6 mmol dm-3. The effects of WR-255591 on the induction and… Expand
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