Radiopharmacological profiles of tracers under pathophysiological conditions. 99mTc-methylene diphosphonate uptake by bone in altered thyroid status.

Abstract

The uptake of 99mTc-MDP, a skeletal radiotracer, was studied at early and late (3 h) time intervals in rats induced with altered thyroid status. Thyroid dysfunction resulted in disturbances in bone mineral metabolism. Rats rendered hypothyroid showed an overall retardation in growth and also considerably reduced skeletal uptake, especially at early time… (More)

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