Radionuclides linked to a CD74 antibody as therapeutic agents for B-cell lymphoma: comparison of Auger electron emitters with beta-particle emitters.

@article{Govindan2000RadionuclidesLT,
  title={Radionuclides linked to a CD74 antibody as therapeutic agents for B-cell lymphoma: comparison of Auger electron emitters with beta-particle emitters.},
  author={Serengulam V. Govindan and David M. Goldenberg and Sammy E. Elsamra and Gary L. Griffiths and Gaik Lin Ong and Martin W. Brechbiel and Jean A. Burton and Georges Sgouros and Michael J Mattes},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2000},
  volume={41 12},
  pages={
          2089-97
        }
}
UNLABELLED We demonstrated previously that human B-cell lymphomas were effectively and specifically killed in vitro by an antibody to CD74 (LL1) linked to (111)In or other Auger electron emitters. This study was intended to more accurately compare the potency and specificity of 3Auger electron emitters, (111)In, 67Ga, and 125I, and to evaluate beta-particle emitters, 131I and 90Y. The unique property of LL1 is its high level of intracellular uptake. METHODS Raji B-lymphoma cells were… CONTINUE READING

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