Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator.

Abstract

Metabolic reduction can be used to activate prodrugs in hypoxic regions of tumours, but reduction by ionising radiation is also theoretically attractive. Previously, we showed that a cobalt(III) complex containing 8-hydroxyquinoline (8-HQ) and cyclen ligands releases 8-HQ efficiently on irradiation in hypoxic solutions [Ahn G-O, Ware DC, Denny WA, Wilson WR… (More)

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Cite this paper

@article{Ahn2006RadiolyticAC, title={Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator.}, author={G W Ahn and Kimberley J. Botting and Adam Vorn Patterson and David C. Ware and Moana Tercel and William W. Wilson}, journal={Biochemical pharmacology}, year={2006}, volume={71 12}, pages={1683-94} }