Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

@article{Devogelaer1987RadiologicalMO,
  title={Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta},
  author={J. P. Devogelaer and Jacques J. Malghem and Baudouin Maldague and Ch. Nagant de Deuxchaisnes},
  journal={Skeletal Radiology},
  year={1987},
  volume={16},
  pages={360-363}
}
A 12-year-old female suffering fromosteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration of therapy was 1 year. Radiological and clinical improvement was striking. Furthermore, X-rays of the bones showed large, parallel radio-opaque striae, corresponding exactly to the periods of therapy. These were present in all metaphyses. 
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