Radioligand binding and immunoautoradiographic evidence for a lack of toxicity to dopaminergic nerve terminals in human cocaine overdose victims.

@article{Staley1997RadioligandBA,
  title={Radioligand binding and immunoautoradiographic evidence for a lack of toxicity to dopaminergic nerve terminals in human cocaine overdose victims.},
  author={Julie K. Staley and Jeffrey Talbot and Brian J. Ciliax and Gary W. Miller and Allan I. Levey and M P Kung and Hank F Kung and Deborah C. Mash},
  journal={Brain research},
  year={1997},
  volume={747 2},
  pages={219-29}
}
Radioligand binding to and immunolabeling of transport sites associated with monoamine-containing synaptic vesicles affords a novel approach for mapping the integrity of dopaminergic (DAergic) nerve terminals. The present study used [125I]iodovinyltetrabenazine ([125I]TBZ) and a fusion protein antibody directed at the large intraluminal loop of the neuronal vesicular monoamine transporter (hVMAT2-loop) as probes to assess the effects of chronic cocaine use on the integrity of DAergic nerve… CONTINUE READING

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