Radiolabeling polymeric micelles for in vivo evaluation: a novel, fast, and facile method

@inproceedings{Laan2016RadiolabelingPM,
  title={Radiolabeling polymeric micelles for in vivo evaluation: a novel, fast, and facile method},
  author={Adrianus C Laan and Costanza Santini and Laurence Jennings and Marion de Jong and Monique Bernsen and Antonia G. Denkova},
  booktitle={EJNMMI research},
  year={2016}
}
BACKGROUND Single photon emission computed tomography (SPECT) is an indispensable tool in the determination of the in vivo fate of polymeric micelles. However, for this purpose, the micelles need to be radiolabeled, and almost all radiolabeling procedures published to date involve the conjugation of a chelating agent to the constituting polymer, which could actually affect their biodistribution. In this paper, we report a new facile method for radiolabeling polystyrene-b-poly(ethylene oxide… CONTINUE READING