Radiolabeling and in vitro /in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor.

@article{Mu2013RadiolabelingAI,
  title={Radiolabeling and in vitro /in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor.},
  author={Linjing Mu and Daniel Bieri and Roger Slavik and Konstantin Drandarov and Adrienne Mueller and Stjepko {\vC}ermak and Markus Weber and Roger Schibli and Stefanie D. Kr{\"a}mer and Simon M. Ametamey},
  journal={Journal of neurochemistry},
  year={2013},
  volume={126 5},
  pages={616-24}
}
The cannabinoid type 2 (CB2) receptor plays an important role in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer’s disease and is therefore a very promising target for therapeutic approaches as well as for imaging. Based on the literature, we identified one 4-oxoquinoline derivative(designated KD2) as the lead structure. It was synthesized, radiolabeled and evaluated as a potential imaging tracer for CB2. [11C]KD2 was… CONTINUE READING
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