Radiolabeled choline as a proliferation marker: comparison with radiolabeled acetate.

@article{Yoshimoto2004RadiolabeledCA,
  title={Radiolabeled choline as a proliferation marker: comparison with radiolabeled acetate.},
  author={Mitsuyoshi Yoshimoto and Atsuo Waki and Atsushi Obata and Takako Furukawa and Yoshiharu Yonekura and Yasuhisa Fujibayashi},
  journal={Nuclear medicine and biology},
  year={2004},
  volume={31 7},
  pages={859-65}
}
[11C]Choline is a potential tracer to detect tumors, especially brain and prostate cancers. The metabolism of [11C]choline defines the accumulation pattern of [11C]choline in tumors depicted by positron emission tomography. Choline is a precursor of phosphatidylcholine that is a major constituent of membrane lipids. Membrane lipid synthesis as well as DNA synthesis is activated during cell proliferation. We investigated the relation between [14C]choline metabolism and proliferative activity… CONTINUE READING

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