Radiolabeled antibody targeting of the HER-2/neu oncoprotein.

  title={Radiolabeled antibody targeting of the HER-2/neu oncoprotein.},
  author={K De Santes and Dennis Slamon and Stephen K Anderson and Marian W Shepard and Brian M. Fendly and Daniel A Maneval and O Press},
  journal={Cancer research},
  volume={52 7},
The HER-2/neu oncogene encodes a Mr 185,000 transmembrane phosphoglycoprotein which is overexpressed in 25-35% of breast and ovarian neoplasms and portends a poor prognosis. We have studied the feasibility of targeting this oncoprotein, designated p185, with radioiodinated murine monoclonal antibodies (muMABs) 4D5 and 7C2, which recognize distinct epitopes on its extracellular domain. The rates of internalization and catabolism of these antibodies were analyzed by cellular radioimmunoassay and… CONTINUE READING


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Radiolabeled antibody targeting of the HER-2/neu oncoprotein (Abstract)

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