Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.

  title={Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.},
  author={Z P Zhuang and M P Kung and Catherine Hou and Daniel M. Skovronsky and Tamar L. Gur and Karl Ploessl and John Q. Trojanowski and Virginia M-Y Lee and Hank F Kung},
  journal={Journal of medicinal chemistry},
  volume={44 12},
We report for the first time that small molecule-based radiodiodinated ligands, showing selective binding to Abeta aggregates, cross the intact blood-brain barrier by simple diffusion. Four novel ligands showing preferential labeling of amyloid aggregates of Abeta(1-40) and Abeta(1-42) peptides, commonly associated with plaques in the brain of people with Alzheimer's disease (AD), were developed. Two 125I-labeled styrylbenzenes, (E,E)-1-iodo-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene, 12… CONTINUE READING