• Medicine
  • Published in
    Clinical cancer research : an…
    2000

Radioimmunoguided surgery in colorectal cancer using a genetically engineered anti-CEA single-chain Fv antibody.

@article{Mayer2000RadioimmunoguidedSI,
  title={Radioimmunoguided surgery in colorectal cancer using a genetically engineered anti-CEA single-chain Fv antibody.},
  author={Astrid Mayer and Eleni Tsiompanou and D O'Malley and Geoffrey M Boxer and J Bhatia and Aiden A. Flynn and Kerry A Chester and Brian R. Davidson and Alan A. Lewis and M C Winslet and Amar P Dhillon and Andrew J. W. Hilson and Richard H. J. Begent},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 5},
  pages={
          1711-9
        }
}
In radioimmunoguided surgery (RIGS), a radiolabeled antibody is given i.v. before surgery and a hand-held gamma-detecting probe is used to locate tumor in the operative field. The rapid blood clearance and good tumor penetration of single-chain Fv antibodies (scFv) offer potential advantages over larger antibody molecules used previously for RIGS. A Phase I clinical trial is reported on RIGS with scFv (MFE-23-his) to carcinoembryonic antigen (CEA). Thirty-four patients undergoing surgery for… CONTINUE READING

Citations

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ANTIBODIES AGAINST TUMIOR SURFACE ANTIGENS

  • 2017
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Intra-operative tumour detection and staging in colorectal cancer surgery.

  • Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • 2012

References

Publications referenced by this paper.
SHOWING 1-10 OF 16 REFERENCES

In vitro and in vivo characterisation of a recombinant carboxypeptidase G2::anti-CEA scFv fusion protein.

  • Immunotechnology : an international journal of immunological engineering
  • 1996
VIEW 1 EXCERPT