Radioimmunoassay of meterelin and pharmacokinetics after single injection and implant administration in dogs.

@article{Hudon1997RadioimmunoassayOM,
  title={Radioimmunoassay of meterelin and pharmacokinetics after single injection and implant administration in dogs.},
  author={E. Hudon and J. Rondeau and V. Lenaerts and P. W{\"u}rthrich and F. Boutignon and R. Deghenghi and S. Marleau and N. Yamaguchi and A. Adam and H. Ong},
  journal={Journal of pharmaceutical sciences},
  year={1997},
  volume={86 2},
  pages={
          172-8
        }
}
A sensitive and specific radioimmunoassay for a novel luteinizing-hormone-releasing-hormone (LHRH) agonist, [2-Me-D-Trp6, DesGly10]LHRH ethylamide (meterelin), was developed for documenting the pharmacokinetic parameters of this peptide following its intravenous (iv) and subcutaneous (sc) administration in dogs. The assay was also used for monitoring meterelin in plasma following its release from d,l-lactide-glycolide implants in the same species. Rabbit antisera generated against [DespyroGlu1… Expand
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