Radioimmunoassay for serum paraquat.


Two variants of a radioimmunoassay for the bipyridylium herbicide Paraquat are described. Both employ antiserum raised to Paraquat-BSA which has been covalently linked to particulate solid-phase support media. The rapid assay for clinical use employs a [3H] Paraquat tracer, requires no agitation and yields results in the range 10--2500 ng/ml serum in 20 min from receipt of sample. The more sensitive assay, designed for research purposes, employs a 125iodinated tracer, requires 2 h continuous agitation but can detect Paraquat at 0.1 ng/ml in simple aqueous solution or 0.25 ng/ml serum. Results from rapid clinical assay agree well with the existing colorimetric method.

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@article{Fatori1980RadioimmunoassayFS, title={Radioimmunoassay for serum paraquat.}, author={Daniel Fatori and W. M. Hunter}, journal={Clinica chimica acta; international journal of clinical chemistry}, year={1980}, volume={100 2}, pages={81-90} }