Radioimmunoassay for Ceronapril, a New Angiotensin‐Converting Enzyme Inhibitor, and Its Application to a Pharmacokinetic Study in Healthy Male Volunteers

@article{Tu1992RadioimmunoassayFC,
  title={Radioimmunoassay for Ceronapril, a New Angiotensin‐Converting Enzyme Inhibitor, and Its Application to a Pharmacokinetic Study in Healthy Male Volunteers},
  author={Jan-I. Tu and John Brennan and Bruce Stouffer and Subbarao Mantha and N Turabi and H M Tsay},
  journal={Therapeutic Drug Monitoring},
  year={1992},
  volume={14},
  pages={209–219}
}
Ceronapril is a member of a new chemical class of angiotensin-converting enzyme inhibitors being developed by The Bristol-Myers Squibb Pharmaceutical Research Institute. A radioimmunoassay (RIA) has been developed for the measurement of ceronapril in biological fluids. The RIA has a range of 0 to 500 ng/ml and has the sensitivity to detect 1.0 ng/ml of ceronapril. Satisfactory zero binding and sensitivity were obtained after a 2-h incubation at room temperature or overnight at 4°. Separation of… Expand
1 Citations
Distribution of the dipeptide transporter system along the gastrointestinal tract of rats based on absorption of a stable and specific probe, SQ-29852.
TLDR
On the basis of the recovery of [14C]SQ-29852 in urine, the DTS is apparently distributed throughout the entire GI tract of rats, including the proximal colon, which is consistent with previously reported results on the absorption of natural dipeptides in humans and rats and immunohistochemical evaluation in rats; however, they disagree with a recent report in humans with amoxicillin. Expand