Radiofluorination with xenon difluoride: a new high yield synthesis of [18F]2-fluro-2-deoxy-D-glucose.

Abstract

The reaction between [18F]xenon difluoride, 3,4,6-tri-O-acetyl-D-glucal and boron trifluoride in ether gives exclusively [18F )3,4,6-tri-O-acetyl-2-fluoro-2-deoxy-D-glucopyranosyl fluoride, which is hydrolysed with 1 N HCl to [18F]2-fluoro-2-deoxy-D-glucose. The overall chemical yield is 75%; the radiochemical yield is 20%. The procedure takes 45 min.

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@article{Sood1983RadiofluorinationWX, title={Radiofluorination with xenon difluoride: a new high yield synthesis of [18F]2-fluro-2-deoxy-D-glucose.}, author={Subeena Sood and Gunter Firnau and E. Stephen Garnett}, journal={The International journal of applied radiation and isotopes}, year={1983}, volume={34 4}, pages={743-5} }