Radiofluorination of PSMA-HBED via Al18F2+ Chelation and Biological Evaluations In Vitro

@article{Malik2015RadiofluorinationOP,
  title={Radiofluorination of PSMA-HBED via Al18F2+ Chelation and Biological Evaluations In Vitro},
  author={Noeen Malik and Benjamin Baur and Gordon Winter and Sven Norbert Reske and Ambros J Beer and Christoph Solbach},
  journal={Molecular Imaging and Biology},
  year={2015},
  volume={17},
  pages={777-785}
}
PurposeGa-68-labeled prostate-specific membrane antigen (PSMA) ligands have been used clinically for positron emission tomography (PET) imaging of prostate cancer. However, F-18-labeled compounds offer several advantages, including the potential for delayed imaging, high starting activities enabling multidose preparation, and improved spatial resolution in PET. For F-18 labeling of peptides conjugated with a suitable chelator, a fast and feasible method is the use of [Al18F]2+. In the present… 

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