Radiofluorinated L-m-Tyrosines: New In-Vivo Probes for Central Dopamine Biochemistry

@article{Barrio1996RadiofluorinatedLN,
  title={Radiofluorinated L-m-Tyrosines: New In-Vivo Probes for Central Dopamine Biochemistry},
  author={J. Barrio and S. Huang and D. C. Yu and W. Melega and J. Quintana and S. Cherry and A. Jacobson and M. Namavari and N. Satyamurthy and M. Phelps},
  journal={Journal of Cerebral Blood Flow & Metabolism},
  year={1996},
  volume={16},
  pages={667 - 678}
}
In this work, we introduce 6-[18F]fluoro-L-m-tyrosine (6-FMT) and compare its in-vivo kinetic and biochemical behaviors in monkeys and rodents with those of 4-FMT and 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (DOPA) (FDOPA). These radiofluorinated m-tyrosine presynaptic dopaminergic probes, resistant to peripheral 3-O-methylation, offer a nonpharmacological alternative to the use of catechol-O-methyltransferase inhibitors. Like FDOPA, 4-FMT and 6-FMT are analogs that essentially follow the L… Expand
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