Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener.

@article{Kiesewetter2002RadiochemicalSA,
  title={Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener.},
  author={Dale O. Kiesewetter and Elaine M. Jagoda and John E. Starrett and Valentin K. Gribkoff and Piyasena Hewawasam and Nugahally Srinivas and Daniel Salazar and William C. Eckelman},
  journal={Nuclear medicine and biology},
  year={2002},
  volume={29 1},
  pages={55-9}
}
The racemate 1, ((+/-)-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)- 2H-indol-2-one), is a potent, specific and novel opener of cloned large-conductance, calcium-activated (maxi-K) potassium channels. One of its enantiomers, BMS-204352 (MaxiPost), is undergoing clinical evaluation for efficacy in patients with suspected acute stroke. In the current study, we have prepared [(18)F]-labeled 1 using a silver assisted nucleophilic substitution to examine its distribution and… CONTINUE READING

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