Radiobiology of radioimmunotherapy: targeting CD20 B-cell antigen in non-Hodgkin's lymphoma.

@article{Hernndez2004RadiobiologyOR,
  title={Radiobiology of radioimmunotherapy: targeting CD20 B-cell antigen in non-Hodgkin's lymphoma.},
  author={Ma. del Carmen Salazar Hern{\'a}ndez and Susan J. Knox},
  journal={International journal of radiation oncology, biology, physics},
  year={2004},
  volume={59 5},
  pages={
          1274-87
        }
}
The radiobiology of radioimmunotherapy is an important determinant of both the toxicity and the efficacy associated with the treatment of B-cell non-Hodgkin's lymphoma with radiolabeled anti-CD20 monoclonal antibodies. The properties of the target, CD20, and the mechanisms of action of both the monoclonal antibodies and the associated exponentially decreasing low-dose-rate radiotherapy are described. The radiation dose and dose-rate effects are discussed and related to both the tumor responses… CONTINUE READING
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