Radiobiological modelling of the therapeutic ratio for the addition of synchronous chemotherapy to radiotherapy in locally advanced squamous cell carcinoma of the head and neck.

@article{Hartley2010RadiobiologicalMO,
  title={Radiobiological modelling of the therapeutic ratio for the addition of synchronous chemotherapy to radiotherapy in locally advanced squamous cell carcinoma of the head and neck.},
  author={Andrew Hartley and Paul Sanghera and John Glaholm and Hisham Mehanna and Chris C McConkey and Jack Fowler},
  journal={Clinical oncology (Royal College of Radiologists (Great Britain))},
  year={2010},
  volume={22 2},
  pages={125-30}
}
AIMS To model the therapeutic gain from the addition of synchronous chemotherapy to radiotherapy in locally advanced head and neck cancer. MATERIALS AND METHODS Refinements to previous methodology, including the derivation of weighted estimates of key parameters from randomised studies and the use of the expected mucosal biologically effective dose concept, have been used to produce an evidence-based assessment of the benefit from the addition of chemotherapy when considering acute grade 3… CONTINUE READING