Radioactive gold nanoparticles in cancer therapy: therapeutic efficacy studies of GA-198AuNP nanoconstruct in prostate tumor-bearing mice.

@article{Chanda2010RadioactiveGN,
  title={Radioactive gold nanoparticles in cancer therapy: therapeutic efficacy studies of GA-198AuNP nanoconstruct in prostate tumor-bearing mice.},
  author={Nripen Chanda and Para Kan and Lisa D. Watkinson and Ravi Shukla and Ajit Zambre and Terry L. Carmack and Hendrik Engelbrecht and John R. Lever and Kavita Katti and Genevieve M. Fent and Stan W. Casteel and Chip J Smith and William H. Miller and Silvia S Jurisson and Evan Boote and James D Robertson and Cathy Sue Cutler and Marina A Dobrovolskaia and Raghuraman Kannan and Kattesh V. Katti},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2010},
  volume={6 2},
  pages={201-9}
}
UNLABELLED Biocompatibility studies and cancer therapeutic applications of nanoparticulate beta-emitting gold-198 (198Au; beta(max) = 0.96 MeV; half-life of 2.7 days) are described. Gum arabic glycoprotein (GA)-functionalized gold nanoparticles (AuNPs) possess optimum sizes (12-18 nm core diameter and 85 nm hydrodynamic diameter) to target individual tumor cells and penetrate through tumor vasculature and pores. We report the results of detailed in vivo therapeutic investigations demonstrating… CONTINUE READING
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