Radio-immunoassay for formyl methionyl leucyl phenylalanine. II. Demonstration of an enterohepatic circulation of immunoreactive bacterial chemotactic peptides in man.

@article{Roberts1990RadioimmunoassayFF,
  title={Radio-immunoassay for formyl methionyl leucyl phenylalanine. II. Demonstration of an enterohepatic circulation of immunoreactive bacterial chemotactic peptides in man.},
  author={Elisabeth C Roberts and C H Hobson and Raymond P. Anderson and Vinton S. Chadwick},
  journal={Journal of gastroenterology and hepatology},
  year={1990},
  volume={5 1},
  pages={38-43}
}
Bacterial chemotactic peptides (F-met-oligopeptides) are secreted by several species of commensal enteric bacteria and can be assayed by bioassay techniques in human colonic luminal fluid. We have previously demonstrated intestinal absorption and enterohepatic circulation of radiolabelled F-met peptides introduced into rat colon, and an eightfold increase in absorption and biliary excretion in rats with experimental colitis. This paper describes the application of a radio-immunoassay to… CONTINUE READING
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