Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires.

Abstract

We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

Cite this paper

@article{Hopkins2017RadioFL, title={Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires.}, author={X . Sun - Johns Hopkins and Waqas Amin Gill and Rosemarie Kringel and Guankui Wang and Jamie M Hass and Suresh Acharya and Jungrae Park and In Tak Jeon and Boo Hyun An and Ji Sung Lee and Jong Eun Ryu and Rod Hill and David N. McIlroy and Young Keun Kim and Daniel Choi}, journal={Nanotechnology}, year={2017}, volume={28 3}, pages={03LT01} }