Radio fluorination and positron emission tomography (PET) as a new approach to study the in vivo distribution and elimination of the advanced glycation endproducts N epsilon-carboxymethyllysine (CML) and N epsilon-carboxyethyllysine (CEL).

@article{Bergmann2001RadioFA,
  title={Radio fluorination and positron emission tomography (PET) as a new approach to study the in vivo distribution and elimination of the advanced glycation endproducts N epsilon-carboxymethyllysine (CML) and N epsilon-carboxyethyllysine (CEL).},
  author={R. P. H. M. Bergmann and Ruediger Helling and Christoph Heichert and Matthias Scheunemann and Peter M{\"a}ding and Holm Wittrisch and Bernd Johannsen and Thomas Henle},
  journal={Die Nahrung},
  year={2001},
  volume={45 3},
  pages={
          182-8
        }
}
After synthesis of fluorine-18 labelled analogues by [18F]fluorobenzoylation at the alpha-amino group, biodistribution and elimination of individual advanced glycation endproducts, namely N epsilon-carboxymethyllysine and N epsilon-carboxyethyllysine, were studied in comparison to lysine in rats after intravenous injection using positron emission tomography (PET). The [18F]radiofluorinated amino acids were fast distributed via the blood, followed by a rapid excretion through the kidneys… CONTINUE READING

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