Radio-copper-labeled Cu-ATSM: an indicator of quiescent but clonogenic cells under mild hypoxia in a Lewis lung carcinoma model.
@article{Oh2009RadiocopperlabeledCA, title={Radio-copper-labeled Cu-ATSM: an indicator of quiescent but clonogenic cells under mild hypoxia in a Lewis lung carcinoma model.}, author={Myungmi Oh and Takeshi Tanaka and Masato Kobayashi and Takako Yoshino Furukawa and Tetsuya Mori and Takashi Kudo and Shigeharu Fujieda and Yasuhisa Fujibayashi}, journal={Nuclear medicine and biology}, year={2009}, volume={36 4}, pages={ 419-26 } }
52 Citations
Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+ highly tumorigenic cells in mouse colon carcinoma.
- BiologyNuclear medicine and biology
- 2010
(64)Cu-ATSM therapy targets regions with activated DNA repair and enrichment of CD133(+) cells in an HT-29 tumor model: Sensitization with a nucleic acid antimetabolite.
- BiologyCancer letters
- 2016
Radiolabeled Cu-ATSM as a novel indicator of overreduced intracellular state due to mitochondrial dysfunction: studies with mitochondrial DNA-less ρ0 cells and cybrids carrying MELAS mitochondrial DNA mutation.
- BiologyNuclear medicine and biology
- 2012
64Cu-ATSM Reflects pO2 Levels in Human Head and Neck Cancer Xenografts but Not in Colorectal Cancer Xenografts: Comparison with 64CuCl2
- MedicineThe Journal of Nuclear Medicine
- 2016
Data from colorectal cancer xenografts indicated that 64Cu-ATSM may not be a hypoxia marker in all tumor types, and data from FaDu and HT29 tumor models indicated that 63Cu-atSM but not 64CuCl2 reflected pO2 measurements, indicating that 64 Cu-AT SM is ahypoxia-specific marker in this tumor type.
62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [18F]Fluorodeoxyglucose and L-Methyl-[11C]Methionine PET
- MedicineAmerican Journal of Neuroradiology
- 2014
62Cu-diacetyl-bis(N4-methylthiosemicarbazone) may be a practical radiotracer in the prediction of glioblastoma multiforme and may provide intratumoral hypoxic information useful in establishing targeted therapeutic strategies for patients with gliOBlastomaMultiforme.
Comparison of intratumoral FDG and Cu-ATSM distributions in cancer tissue originated spheroid (CTOS) xenografts, a tumor model retaining the original tumor properties.
- MedicineNuclear medicine and biology
- 2014
Application of 62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET Imaging to Predict Highly Malignant Tumor Grades and Hypoxia-Inducible Factor-1α Expression in Patients with Glioma
- MedicineAmerican Journal of Neuroradiology
- 2013
It is demonstrated that 62 Cu-ATSM uptake is relatively high in grade IV gliomas and correlates with the MR imaging findings of necrosis, and the 62Cu-AT SM T/B ratio showed significant correlation with HIF-1α expression.
PET Imaging of Hypoxia-Inducible Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable Streptavidin and a Novel 18F-Labeled Biotin Derivative
- Biology, ChemistryMolecular Imaging and Biology
- 2010
Pretargeting with POS and 18F-FBB is an effective approach for PET imaging of HIF-1-active areas in tumors.
Alteration of Cellular Reduction Potential Will Change 64Cu-ATSM Signal With or Without Hypoxia
- BiologyThe Journal of Nuclear Medicine
- 2019
It is demonstrated that Copper(II)-diacetyl-bis(4-methylthiosemicarbazonato) (Cu-ATSM) signal is dependent on cellular redox state, irrespective of hypoxia, which has implications for the use of 64Cu- ATSM as a predictive marker for redox therapies, though further in vivo work is needed.
Correlation of hypoxia PET tracer uptake with hypoxic radioresistance in cancer cells: PET biomarkers of resistance to stereotactic radiation therapy?
- Biology, MedicineNuclear medicine and biology
- 2022
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