Radicicol Binding to Swol / Hsp 90 and Inhibition of Temperature-sensitive Cell Cycle Mutants of FissionGrowth of Specific Yeas

A panel screening using cdc mutants of Schizosaccharomyces pombe identified radicicol as a potent growth inhibitor of certain mutants at the permissive temperature. The strains sensitive to radicicol were cdb7, cdcll, and cdc14, al] of which are defectiye in early septum formation. Cytokinesis but not nuclear diyision of these mutants was inhibited by… CONTINUE READING