Radicals from S-adenosylmethionine and their application to biosynthesis.

  • Peter L Roach
  • Published 2011 in Current opinion in chemical biology


The radical SAM superfamily of enzymes catalyzes a broad spectrum of biotransformations by employing a common obligate intermediate, the 5'-deoxyadenosyl radical (DOA). Radical formation occurs via the reductive cleavage of S-adenosylmethionine (SAM or AdoMet). The resultant highly reactive primary radical is a potent oxidant that enables the… (More)
DOI: 10.1016/j.cbpa.2010.11.015


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