Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit.

@article{Girennavar2007RadicalSA,
  title={Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit.},
  author={Basavaraj Girennavar and Guddarangavvanahally K Jayaprakasha and Y. Jadegoud and G A Nagana Gowda and Bhimanagouda S Patil},
  journal={Bioorganic & medicinal chemistry},
  year={2007},
  volume={15 11},
  pages={3684-91}
}
Grapefruit juice has been shown to increase the oral bioavailability of several clinically important drugs by inhibiting first pass metabolism. Several compounds in grapefruit juice have shown different biological activities. Unique among them are furocoumarins with potent inhibitory activity against cytochrome P450 enzymes. In the present study, two bioactive compounds were isolated from grapefruit juice and grapefruit peel oil. The purity of the isolated compounds has been analyzed by HPLC… CONTINUE READING

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