Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents

  title={Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents},
  author={Andreana N. Assimopoulou and Zacharias Sinakos and Vassilios P. Papageorgiou},
  journal={Phytotherapy Research},
Radical scavenging activity is involved in aging processes, antiinflammatory, anticancer and wound healing activity. Hence, in the present study the DPPH radical scavenging activity of a natural product that possesses biological properties, an extract of Crocus sativus L. (saffron), grown in Crocos, Kozani (Greece), and some of its bioactive constituents (crocin, safranal) was studied. 
Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review
This study provides an updated overview focused on the antioxidant activity of saffron related to its bioactive compounds to design the different functional products in food, medicine and cosmetic industries. Expand
Evaluation of antioxidant activities of saffron stigma and spath as by-product of Crocus sativus L.
  • 2018
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system, potentially leading to damage.1 An antioxidant is a molecule thatExpand
Flavonoids from Trollius europaeus flowers and evaluation of their biological activity
The flavonoid composition of the flowers of Trollius europaeus and the method of isolation thereof is described and an attempt at investigating the antioxidant activity of the isolated flavonoids and the antityrosinaseactivity of the extracts from the investigated material is provided. Expand
Saffron: A repository of medicinal properties
Saffron (stigmas of Crocus sativus L.) has been used for medicinal purposes since decades. Modern pharmacological research confirms large parts of traditional knowledge regarding the medicinalExpand
Chemical Composition, Antioxidant and Antimicrobial Activities of Sanguisorba officinalis L. Extracts
A correlation between the antioxidant activity and composition of tested extracts indicates that flavonoids are the major compounds causing scavenging of free radicals. Expand
Determination of Antioxidant Properties of Six By-Products of Crocus sativus L. (Saffron) Plant Products
PurposeCrocus sativus L. is one of the spices believed to possess antioxidant activities. The stigma of saffron has been widely used as spice for culinary purposes, food colorant and medicinal plant.Expand
Antioxidant and antimicrobial activities in the different extracts of Caspian saffron , Crocus caspius
Nowadays it is very desirable to investigate and discover new antibacterial and antioxidant agents from natural products and medicinal plants. The current study was conducted to examine theExpand
Pharmacological Importance of Crocus sativus Apocarotenoids
This chapter provides an in-depth knowledge about the traditional medicinal uses of saffron and their subsequent pharmacological validation. Expand
Effect of Crocus sativus and its active compounds for the treatment of several diseases: A review
It is demonstrated that crocus sativus extract and its major constituents, crocin, and crocetin, significantly inhibited the growth of certain cancer cells while not effecting normal cells. Expand
Chemical and Medicinal Properties of Saffron
Crocus sativus L. belonging to the family Iridaceae comprises the dried red stigma and is widely cultivated in Iran and other countries such as India and Greece. Saffron contains more than 150Expand


An Update Review of Saffron and its Active Constituents
This paper reviews the literature on recent research on the chemical composition and pharmacological activities of saffron (Crocus sativus) and its active constituents, mainly as antitumoral,Expand
Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro.
Considering its water-solubility and high inhibitory growth effect, crocin is the more promising saffron compound to be assayed as a cancer therapeutic agent. Expand
Determination of saffron (Crocus sativus L.) components in crude plant extract using high-performance liquid chromatography-UV-visible photodiode-array detection-mass spectrometry.
The determination of saffron components in crude plant extracts by high-performance liquid chromatography-UV-visible photodiode-array detection on-line with mass spectrometry is described. The methodExpand
Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice
It is concluded that aqueous and ethanolic extracts of saffron stigma and petal have an antinociceptive effect, as well as acute and/or chronic anti-inflammatory activity. Expand
Crocetin protects against oxidative damage in rat primary hepatocytes.
The data showed that crocetin decreased genotoxicity evaluated with UDS in both systems and inhibited the formation of superoxide anion in the X/XO system and bleached the free radical 1, 1-diphenyl-2- picrylhydrazyl (DPPH). Expand
Saffron chemoprevention in biology and medicine: a review.
Saffron (dimethyl-crocetin) disrupts DNA-protein interactions e.g. topoisomerases II, important for cellular DNA synthesis, according to results indicated significant inhibition in the synthesis of nucleic acids but not protein synthesis. Expand
Antioxidant property of Saffron in man.
The significant fall (P < 0.001) in LOS indicates the potential of Saffron as an antioxidant and indicates the need to investigate further the role of this substance in the treatment of CAD. Expand
Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.).
Results suggest that saffron itself, as well as its carotenoid components might be used as potential cancer chemopreventive agents. Expand
Antioxidants in Nutrition
The efficacy of an antioxidant depends on its reduction potential and kinetics of elimination of diverse free radicals, and these studies may be crucial in optimizing health and increasing longevity by reducing oxidative stress and biological damage. Expand
A quantitative high-performance liquid chromatographic method to analyse commercial saffron (Crocus sativus L.) products.
An HPLC method to check components and purity in commercial saffron by photodiode array detection has been developed. The method was suitable for the standard analysis of commercial saffron.Expand