Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD.

Abstract

Induced pluripotent stem cells (iPSCs) can be created by reprogramming differentiated cells through introduction of defined genes, most commonly Oct4, Sox2, Klf4, and c-Myc (OSKM). However, this process is slow and extremely inefficient. Here, we demonstrate radical acceleration of iPSC creation with a fusion gene between Oct4 and the powerful… (More)
DOI: 10.1002/stem.684

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