Radical-Scavenging Activity of a Sunscreen Enriched by Antioxidants Providing Protection in the Whole Solar Spectral Range

@article{Souza2017RadicalScavengingAO,
  title={Radical-Scavenging Activity of a Sunscreen Enriched by Antioxidants Providing Protection in the Whole Solar Spectral Range},
  author={Carla Souza and Patr{\'i}cia Maria Berardo Gonçalves Maia Campos and Sabine Schanzer and S Albrecht and Silke B. Lohan and J{\"u}rgen Lademann and Maxim E. Darvin and Martina C. Meinke},
  journal={Skin Pharmacology and Physiology},
  year={2017},
  volume={30},
  pages={81 - 89}
}
Background/Aim: The main reason for extrinsic skin aging is the negative action of free radicals. The formation of free radicals in the skin has been associated with ultraviolet (UV) exposure and also to visible (VIS) and near-infrared (NIR) irradiations. The aim of the present study was to evaluate the efficacy of a sunscreen in the whole solar range. Methods: The radical-scavenging activity of a sunscreen in the UV, VIS, and NIR ranges was evaluated using electron paramagnetic resonance… 

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References

SHOWING 1-10 OF 87 REFERENCES
Radical Protection by Sunscreens in the Infrared Spectral Range
TLDR
Four different, commercially available sunscreens and one COLIPA standard are investigated with regard to radical formation in the skin after IR irradiation, using electron paramagnetic resonance spectroscopy to investigate their influence on the radical protection of the skin.
Radical Protection by Differently Composed Creams in the UV/VIS and IR Spectral Ranges
TLDR
It was found that organic UV filters lower radical formation in the UV/VIS range to 35% compared to untreated skin, independent of the presence of AO, whereas physical filters alone were ineffective in theUV/vis range due to the low concentration.
Free radicals induced by sunlight in different spectral regions – in vivo versus ex vivo study
TLDR
Results indicate that radiation exposure in different spectral regions strongly influences radical production in skin and also results in changes in skin lipid composition, which is essential for barrier function.
Irradiation of skin with visible light induces reactive oxygen species and matrix-degrading enzymes.
TLDR
Findings suggest that other portions of the solar spectrum aside from UV, particularly visible light, may also contribute to signs of premature photoaging in skin.
Non-sunscreen photoprotection: antioxidants add value to a sunscreen.
TLDR
The addition of botanical antioxidants and vitamins C and E to a broad-spectrum sunscreen may further decrease UV-induced damage compared with sunscreen alone, and add value when applied topically to human skin in vivo.
The Missing Link – Light-Induced (280–1,600 nm) Free Radical Formation in Human Skin
TLDR
The free radical action spectrum covering UV and visible light (280–700 nm) is determined for the first time, and it is shown that 50% of the total skin oxidative burden was generated by visible light.
Beyond UV radiation: A skin under challenge
TLDR
New molecular mechanisms linking sun and environmental factors to skin ageing have been identified: IR affects mitochondrial integrity and specific heat receptors also mediate some of its effects, tryptophan is a chromophore for UVB, and the aryl hydrocarbon receptor (AhR) is activated by light and xenobiotics to alter skin physiology.
Sunscreens inadequately protect against ultraviolet-A-induced free radicals in skin: implications for skin aging and melanoma?
TLDR
The disparity between these protection factors suggests that prolonged sunbathing (encouraged by use of these creams) would disproportionately increase exposure to ultraviolet A and consequently the risk of ultraviolet-A-related skin damage.
Protective effects of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers.
...
1
2
3
4
5
...