Radical-Mediated Dearomatization of Indoles with Sulfinate Reagents for the Synthesis of Fluorinated Spirocyclic Indolines.

Abstract

The dearomative introduction of trifluoromethyl and 1,1-difluoroethyl radicals, generated from their corresponding sulfinate salts, into the C2 position of indole derivatives allows the diastereoselective synthesis of three-dimensional 3,3-spirocyclic indolines over C-H functionalized indoles. 
DOI: 10.1021/acs.orglett.7b03155

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Cite this paper

@article{Ryzhakov2017RadicalMediatedDO, title={Radical-Mediated Dearomatization of Indoles with Sulfinate Reagents for the Synthesis of Fluorinated Spirocyclic Indolines.}, author={Dmytro Ryzhakov and Maxime Jarret and R{\'e}gis Guillot and Cyrille Kouklovsky and Guillaume Vincent}, journal={Organic letters}, year={2017}, volume={19 23}, pages={6336-6339} }