Radical [3 + 2]-annulation of divinylcyclopropanes: rapid synthesis of complex meloscine analogs.

@article{Zhang2014Radical,
  title={Radical [3 + 2]-annulation of divinylcyclopropanes: rapid synthesis of complex meloscine analogs.},
  author={Hanmo Zhang and Kyu Ok Jeon and Everett B Hay and Steven J Geib and Dennis P Curran and Matthew G Laporte},
  journal={Organic letters},
  year={2014},
  volume={16 1},
  pages={94-7}
}
A radical [3 + 2]-divinylcyclopropane annulation cascade has been extended to encompass five D-ring variants of the meloscine/epimeloscine core structure. Representative ABCD tetracyclic intermediates were further elaborated with novel substituted E-rings through subsequent transformations of advanced intermediates that provided opportunities for late-stage… CONTINUE READING